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Welcome to Worm Cool Kit!

This site contains bioinformatic tools created and developed in Ronen Zaidel Bar's Lab, for the benefit of the field of genetic research in Caenorhabditis elegans.

A prime use of this bioinformatic toolkit is to accelerate the study of human genetic variations that are known or suspected to cause disease by modeling them in C. elegans.

Although worms and humans differ greatly in their anatomy and physiology, at the cellular and molecular levels they are remarkably similar, and important genes often demonstrate a high degree of evolutionary conservation.

Therefore, the same mutation that causes a disease in humans might cause a problem in the development and/or life span of a worm.

The bioinformatic tools on this website assist in finding worm orthologs to human genes and vice versa, determining whether specific amino acids are conserved between the orthologs, selecting CRISPR-Cas9 RNA guides and providing DNA template designs for introducing point mutations in the C.elegans genome.